Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic …

Gene fusions play a critical role in cancer progression. The mechanisms underlying their
genesis and cell type specificity are not well understood. About 50% of human prostate …

Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family …

Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS
transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical …

Arising from: Tomlins et al. Nature448, 595–599 (2007) 10.1038/nature06024; Tomlins et al.
reply The first recurrent translocation event in prostate cancer has been recently described; it …

TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in
the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN) …

Novel recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS
family members ERG, ETV1, or ETV4 have been recently identified as a common molecular …

Emerging molecular and clinical data suggest that ETS fusion prostate cancer represents a
distinct molecular subclass, driven most commonly by a hormonally regulated promoter and …

Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS
family transcription factors ERG, ETV1, and ETV4 have been identified in the majority of …

Chromosomal translocations involving the ERG locus are frequent events in human prostate
cancer pathogenesis; however, the biological role of aberrant ERG expression is …