Gliomas are the most common intracranial tumors in humans. The most malignant among
these tumors is glioblastoma (GBM), with an incidence of 3–5 out of 100,000 persons in …

High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This
has led to extensive research focusing on arresting glioma cell migration. Cell migration …

Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

Glioblastoma multiforme is the most common and lethal primary malignant brain tumor.
Although considerable progress has been made in technical proficiencies of surgical and …

Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients
die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments …

Glioma is the most common primary brain tumor, and its prognosis is poor. Glioma cells are
highly invasive to the brain parenchyma. It is difficult to achieve complete resection due to …

Glioblastomas are the most common and lethal form of malignant primary brain tumors.
Although some progress has been made, the impact of recent advances in multimodality …

Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

A hallmark of gliomas is the ability of individual tumor cells to infiltrate the neural tissue and
extend beyond the visible borders of the tumor. Current treatments fail to remove these …

The efficacy of treating malignant gliomas with adjuvant therapies remains largely
unsuccessful due to the inability to effectively target invading cells. Although our …