Abstract Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the
synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2 …

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …

We conducted a double-blind, placebo-controlled study to investigate the safety,
pharmacokinetics, and immunological properties of interleukin-10 (IL-10) administration in …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Publisher Summary This chapter focuses on properties and functions of interleukin-10. IL10
inhibits several macrophage functions, including some microbicidal properties and …

Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell
populations. Its main biological function seems to be the limitation and termination of …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

Interleukin-12 is a heterodimeric cytokine produced by phagocytic cells, professional
antigen-presenting cells such as dendritic cells and skin Langerhans cells, and B cells …

Since the original description of interleukin-10, a wealth of information concerning its
biological properties has been gathered. Studies in vitro have rapidly identified both …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …