As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Every organism across the tree of life compacts and organizes its genome with architectural
chromatin proteins. While eukaryotes and archaea express histone proteins, the …

To fit within the confines of the cell, bacterial chromosomes are highly condensed into a
structure called the nucleoid. Despite the high degree of compaction in the nucleoid, the …

Recent advances in bacterial cell biology have revealed unanticipated structural and
functional complexity, reminiscent of eukaryotic cells. Particular progress has been made in …

Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

Bacterial genomes are functionally organized and compactly folded into a structure referred
to as bacterial chromatin or the nucleoid. An important role in genome folding is attributed to …

The bacterial chromosome is organized into loops, which constitute topologically isolated
domains. It is unclear which proteins are responsible for the formation of the topological …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Structural maintenance of chromosomes (SMC) complexes organize chromosomes
ubiquitously, thereby contributing to their faithful segregation. We demonstrate that under …

Chromosomes of a broad range of species, from bacteria to mammals, are structured by
large topological domains whose precise functional roles and regulatory mechanisms …