Cell cycle re-entry of quiescent T lymphocytes regulated by cdk2 is required for antigen-
specific clonal expansion and generation of productive T cell responses. Recently, we …

Graft versus host disease (GvHD), mediated by donor T cells, remains the primary cause of
non-relapse mortality after allogeneic hematopoietic stem cell transplantation and novel …

A large body of research has established the importance of costimulatory signals and
proliferation for the generation of productive T cell immune responses. While costimulation …

The proliferation of a few antigen-reactive lymphocytes into a large population of effector
cells is a fundamental property of adaptive immunity. The cell division that fuels this process …

The cyclin‐dependent kinase inhibitor (CDKi) drugs such as R‐roscovitine have emerged as
potential anti‐inflammatory, pharmacological agents that can influence the resolution of …

Myelosuppression is one the most frequent side effects of chemotherapy. New agents that
more selectively target cancer cells have been developed in attempt to improve the effects …

Peripheral negative selection of cycling T cells after TCR engagement and deletion of
activated T cells after an immune response occur by an apoptotic process termed activation …

The cyclin-dependent kinase (CDK) inhibitor roscovitine is under evaluation in clinical trials
for its antiproliferative properties. Roscovitine arrests cell cycle progression in G1 and in G2 …

The transit of T lymphocytes through the cell cycle in response to extracellular signals is
controlled in large part by the ordered expression and degradation of cyclins and cyclin …

Proliferation of Ag-specific T cells is central to the development of protective immunity. The
concomitant stimulation of the TCR and CD28 programs resting T cells to IL-2-driven clonal …