Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations

G Agbayani, Y Jia, B Akache, V Chandan… - Human vaccines & …, 2020 - Taylor & Francis
Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic
glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen …

Sulfated archaeal glycolipid archaeosomes as a safe and effective vaccine adjuvant for induction of cell-mediated immunity

MJ McCluskie, L Deschatelets… - Human vaccines & …, 2017 - Taylor & Francis
Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain
of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability …

Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants

B Akache, FC Stark, U Iqbal, W Chen, Y Jia… - Human Vaccines & …, 2018 - Taylor & Francis
Archaeosomes are liposomes comprised of ether lipids derived from various archaea.
Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal …

[HTML][HTML] Sulfated archaeol glycolipids: Comparison with other immunological adjuvants in mice

B Akache, FC Stark, Y Jia, L Deschatelets, R Dudani… - PLoS …, 2018 - journals.plos.org
Archaeosomes are liposomes traditionally comprised of total polar lipids (TPL) or semi-
synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glyco-and amino …

A comparison of the immune responses induced by antigens in three different archaeosome-based vaccine formulations

Y Jia, B Akache, L Deschatelets, H Qian… - International journal of …, 2019 - Elsevier
Archaeosomes are liposomes composed of natural or synthetic archaeal lipids that can be
used as adjuvants to induce strong long-lasting humoral and cell-mediated immune …

Archaeal lipid vaccine adjuvants for induction of cell-mediated immunity

K Haq, Y Jia, L Krishnan - Expert review of vaccines, 2016 - Taylor & Francis
Introduction: Liposomal vesicles (archaeosomes) composed of total polar lipids (TPL) or
semi-synthetic glycerolipids, unique to the domain Archaea, constitute potent vaccine …

Archaeosomes as Self-adjuvanting Delivery Systems for Cancer Vaccines*

L Krishnan, G Dennis Sprott - Journal of drug targeting, 2003 - Taylor & Francis
Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen
for induction of humoral and cell-mediated immunity. Because induction of CD8+ cytotoxic T …

Safety of archaeosome adjuvants evaluated in a mouse model

GB Patel, A Omri, L Deschatelets… - Journal of Liposome …, 2002 - Taylor & Francis
Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea,
demonstrate great potential as immunomodulating carriers of soluble antigens, promoting …

[HTML][HTML] Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology

Y Jia, G Agbayani, V Chandan, U Iqbal, R Dudani… - Pharmaceutics, 2022 - mdpi.com
Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven
to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or …

Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum

L Krishnan, CJ Dicaire, GB Patel… - Infection and …, 2000 - Am Soc Microbiol
Ether glycerolipids extracted from various archaeobacteria were formulated into liposomes
(archaeosomes) possessing strong adjuvant properties. Mice of varying genetic …