There is growing recognition that nonnicotine factors, such as the sensory stimuli associated
with smoking, can play a critical role in the maintenance of cigarette smoking. However, little …

Activation of the mesolimbic dopamine system is a critical component underlying addictive
behaviors, including smoking. It has been hypothesized that the initial effect of nicotine on …

Tobacco use is often associated with long‐term addiction as well as high risk of relapse
following cessation. This is suggestive of persistent neural adaptations, but little is known …

Cotinine, a major metabolite of nicotine, has produced improved learning and memory in
rodents and non-human primates and corrects apomorphine-induced loss of pre-pulse …

Rationale: Repeated exposure to addictive drugs causes neuroadaptive alterations that are
proposed to increase the incentive motivation to consume drugs and to decrease the ability …

Behavioural effects of d-and l-nicotine, d-and l-nornicotine and l-cotinine were studied in two
paradigms. In experiment 1, rats responded under a multiple fixed-interval (FI) 5 min, fixed …

Abstract Schechter, Martin D. and Suzanne M. Meehan: Dopamine Mediation of the
Stimulant Generalization of Nicotine. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993 …

Rats were pretreated with saline or nicotine (1.5 mg/kg per day) by subcutaneously
implanting each animal with an Alzet osmotic mini-pump which continuously released saline …

A major goal of basic nicotine research is to obtain information useful to the clinician in
determining why and how people become dependent on this substance via the use of …

Mice of the C56BL/6J strain were trained to discriminate between nicotine (1.2 mg/kg) and
saline in a two-lever drug discrimination procedure under a tandem variable-interval 60 s …