Behavioural sensitisation has been suggested to play a role in the acquisition and
maintenance of addictive behaviour. The aim of the present study was to assess nicotine …

Published findings of intravenous nicotine self-injection indicate that the reinforcing
properties of nicotine are weak when the drug is made available according to continuous …

The behavioral and neurochemical manifestations in rats 24 h following the cessation of 14-
day nicotine administration were investigated. Animals were implanted subcutaneously with …

To assess the role of nicotine receptors in the nucleus accumbens on locomotor activity we
bilaterally implanted guide cannulae for later injection of (−)-nicotine into the nucleus …

Repeated exposure to nicotine increases both the number of central nicotinic receptors and
the behavioral stimulant effect of nicotine. In the present experiments, the behavioral …

Rationale Nicotine may enhance the reinforcing value of other reinforcers. It is unclear
whether nicotine enhances responding maintained by all reinforcers or whether there are …

Rationale: Repeated administration of nicotine leads to an augmentation of its locomotor
activating effects. Although studies have begun to identify the nicotinic receptor subtype (s) …

Tobacco use through cigarette smoking is the leading preventable cause of death in the
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …

Despite the high prevalence of tobacco abuse among adolescents, the neurobiology of
nicotine addiction has been studied mainly in adult animals. Repeated administration of this …