Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate …

P Kettunen, S Løes, T Furmanek, K Fjeld… - 2005 - journals.biologists.com
During development, trigeminal nerve fibers navigate and establish their axonal projections
to the developing tooth in a highly spatiotemporally controlled manner. By analyzing …

Integration of tooth morphogenesis and innervation by local tissue interactions, signaling networks, and semaphorin 3A

K Luukko, P Kettunen - Cell Adhesion & Migration, 2016 - Taylor & Francis
The tooth, like many other organs, develops from both epithelial and mesenchymal tissues,
and has proven to be a valuable tool with which to investigate organ formation and …

Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis

K Luukko, IH Kvinnsland… - Developmental Dynamics, 2005 - Wiley Online Library
Like many other organs, the tooth develops as a result of the epithelial‐mesenchymal
interactions. In addition, the tooth is a well‐defined peripheral target organ for sensory …

[HTML][HTML] Fgfr2b mediated epithelial–mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning

P Kettunen, B Spencer-Dene, T Furmanek… - Mechanisms of …, 2007 - Elsevier
Dental trigeminal nerve fiber growth and patterning are strictly integrated with tooth
morphogenesis, but it is still unknown, how these two developmental processes are …

Secondary induction and the development of tooth nerve supply

K Luukko, K Moe, A Sijaona, T Furmanek… - Annals of Anatomy …, 2008 - Elsevier
During embryogenesis, dental trigeminal axon navigation and patterning in the developing
tooth take place in a highly spatio-temporally directed manner that is tightly linked to tooth …

Coordination of tooth morphogenesis and neuronal development through tissue interactions: lessons from mouse models

K Luukko, P Kettunen - Experimental cell research, 2014 - Elsevier
In addition to being an advantageous model to investigate general molecular mechanisms
of organ formation, the tooth is a distinct target organ for peripheral nerve innervation. These …

Wnt signaling promotes tooth germ development through YAP1-TGF-β signaling

R Nagano, S Fujii, K Hasegawa, H Maeda… - Biochemical and …, 2022 - Elsevier
Tooth germ development involves continuous and sequential steps with reciprocal
interactions between odontogenic epithelium and the adjacent mesenchyme. Several …

Expression patterns of Sema3F, PlexinA4,-A3, Neuropilin1 and-2 in the postnatal mouse molar suggest roles in tooth innervation and organogenesis

A Sijaona, K Luukko, IH Kvinnsland… - Acta Odontologica …, 2012 - Taylor & Francis
Objective. Semaphorins form a family of axon wiring molecules but still little is known about
their role in tooth formation. A class 3 semaphorin, Semaphorin3F (Sema3F), besides acting …

Odontoblast expression of semaphorin 7A during innervation of human dentin

JC Maurin, G Delorme, I Machuca-Gayet, ML Couble… - Matrix biology, 2005 - Elsevier
Semaphorin 7A (SEMA 7A) is a membrane-anchored member of the semaphorin family of
guidance proteins, previously identified in the immune system. Expressed in central and …

Semaphorin 3A controls timing and patterning of the dental pulp innervation

K Moe, A Sijaona, A Shrestha, P Kettunen, M Taniguchi… - Differentiation, 2012 - Elsevier
Timing and patterning of dental pulp innervation are strictly spatio-temporally regulated but it
is still not known how they are controlled at molecular level. We analyzed postnatal …