Aberrant dopamine function in the dorsal striatum and aberrant intrinsic functional
connectivity (iFC) between distinct cortical networks and thalamic nuclei are among the most …

Objective Striatal dopamine dysfunction caused by cortical abnormalities is a leading
hypothesis of schizophrenia. Although prefrontal cortical pathology is negatively correlated …

Importance Despite the well-established role of striatal dopamine in psychosis, current views
generally agree that cortical dysfunction is likely necessary for the emergence of psychotic …

Schizophrenia is characterized by hypoconnectivity or decreased intrinsic functional
connectivity (iFC) between prefrontal-limbic cortices and thalamic nuclei, as well as …

The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system
cause functional abnormalities in the brain that may converge to aberrant salience …

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …

Neuroimaging studies suggest the abnormal structure and function of basal ganglion may
contribute to the pathophysiology of schizophrenia. However, little is investigated about the …

Schizophrenia is hypothesized to arise from disrupted brain connectivity. This
“dysconnectivity hypothesis” has generated interest in discovering whether there is …

Background The striatum is abnormal in schizophrenia and possibly represents a common
neurobiological mechanism underlying psychotic disorders. Resting-state functional …

BackgroundIn patients with schizophrenia in a psychotic episode, intra-striatal intrinsic
connectivity is increased in the putamen but not ventral striatum. Furthermore, multimodal …