Despite improvements in cardiopulmonary resuscitation (CPR) quality, defibrillation
technologies, and implementation of therapeutic hypothermia, less than 10% of out-of …

Purpose Evidence suggests an association between aberrant mitochondrial dynamics and
cardiac diseases. Because myocardial metabolic deficiency caused by insulin resistance …

Aims Mitochondria in adult cardiomyocytes exhibit static morphology and infrequent
dynamic changes, despite the high abundance of fission and fusion regulatory proteins in …

Aims Disturbance of the balance between mitochondrial fission and fusion has been
implicated in cerebral ischemia and several neurodegenerative diseases, whereas the …

Aims Genetic and pharmacological inhibition of mitochondrial fission induced by acute
myocardial ischaemia/reperfusion injury (IRI) has been shown to reduce myocardial infarct …

Mitochondrial mass imbalance is one of the key causes of cardiovascular dysfunction after
hypoxia. The activation of dynamin-related protein 1 (Drp1), as well as its mitochondrial …

Background/Aims: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen
species (ROS) production and apoptosis in cardiomyocytes subjected to …

Mitochondrial dysfunction is a major contributor to myocyte loss and the development of
heart failure. Myocytes have quality control mechanisms to retain functional mitochondria by …

Mitochondrial dysfunction is a salient feature of myocardial ischemia/reperfusion injury
(MIRI), while the potential mechanism of mitochondrial dynamics disorder remains unclear …

The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here,
we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that …