Interferon-γ promotes inflammation and development of T-cell lymphoma in HTLV-1 bZIP factor transgenic mice

Y Mitagami, J Yasunaga, H Kinosada… - PLoS …, 2015 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) is an etiological agent of several inflammatory
diseases and a T-cell malignancy, adult T-cell leukemia (ATL). HTLV-1 bZIP factor (HBZ) is …

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

Y Satou, J Yasunaga, T Zhao, M Yoshida… - PLoS …, 2011 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of
CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 …

HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling

Y Higuchi, J Yasunaga, Y Mitagami… - Proceedings of the …, 2020 - National Acad Sciences
Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of a T cell neoplasm and
several inflammatory diseases. A viral gene, HTLV-1 bZIP factor (HBZ), induces pathogenic …

HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression

N Yamamoto-Taguchi, Y Satou, P Miyazato… - PLoS …, 2013 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) causes both a neoplastic disease and
inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic …

HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in …

HTLV-1 bZIP factor enhances T-cell proliferation by impeding the suppressive signaling of co-inhibitory receptors

H Kinosada, J Yasunaga, K Shimura, P Miyazato… - PLoS …, 2017 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. To enhance cell-to-cell transmission of HTLV-1, the virus …

HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization

A Tanaka-Nakanishi, J Yasunaga, K Takai… - Cancer research, 2014 - AACR
As the infectious agent causing human adult T-cell leukemia (ATL), the human T-cell
leukemia virus type 1 (HTLV-1) virus spreads in vivo primarily by cell-to-cell transmission …

HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator

T Zhao, Y Satou, K Sugata, P Miyazato… - Blood, The Journal …, 2011 - ashpublications.org
Ctgf, Foxp3, Runx1, and Tsc22d1 genes and suppression of the Id2 gene; such effects were
similar to those by TGF-ß. In particular, HBZ induced Foxp3 expression in naive T cells …

The role of HBZ in HTLV-1-induced oncogenesis

T Zhao - Viruses, 2016 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and
chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense …

HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT)

K Yasuma, J Yasunaga, K Takemoto, K Sugata… - PLoS …, 2016 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) infects CD4+ T cells and induces proliferation
of infected cells in vivo, which leads to the onset of adult T-cell leukemia (ATL) in some …