Four groups of weanling male Wistar rats (Groups A—D) received diethylnitrosamine (DEN,
40 ppm) in their drinking water for four weeks; after a recovery period of two weeks, they …

Seven groups of female Sprague‐Dawley rats (˜ 200 gm initial body weight) were injected ip
with a single subcarcinogenic dose of diethylnitrosamine (40 mg per kg body weight) …

One hundred and fifty-one weanling rats of both sexes were fed control diets or diets
containing 160 ppm diethylnitrosamine (DEN) or 150 ppm N-2-fluorenyl-acetamide (FAA) …

Selenium is an essential micronutrient mineral found mainly in soils and has been shown to
prevent certain cancers in humans and animals. However, the dose and effects of selenium …

Three protocols were used to determine the effects of dietary selenium concentration on the
development of γ-glutamyltranspeptidase (GGT)-positive foci and hepatocellular carcinoma …

Previous studies in animals and humans have shown that selenium compounds can prevent
cancer development. In this work we studied the tumor preventive effect of selenium …

It is generally believed that carcinoma of the human liver is frequently preceded by cirrhosis
(4). In the case of experimental tumors of the liver, such as those produced by feeding p …

Abstract Male Sprague-Dawley rats fed selenium deficient diets received either 0 ppm, 0.15
ppm or 4.0 ppm selenium in the drinking water. Animals were treated with …

This experiment was designed to compare the effect of two selenium sources at the dosage
of therapeutic level on hepatocarcinogenesis and angiogenic cytokines in DEN-induced …

METHODS Eighty female OSU-brown rats were weaned at 35 days of age and didded into
four groups of 20 each. The 40 rats in Groups I and XI were born from parents reared on the …