[HTML][HTML] Stem cell therapies in Alzheimer's disease: applications for disease modeling

Z Si, X Wang - Journal of Pharmacology and Experimental …, 2021 - ASPET
Alzheimer's disease (AD) is a neurodegenerative disease with complex pathologic and
biologic characteristics. Extracellular β-amyloid deposits, such as senile plaques, and …

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer's disease

HE Marei, MUA Khan, A Hasan - Cellular & Molecular Biology Letters, 2023 - Springer
Alzheimer's disease (AD) is a chronic illness marked by increasing cognitive decline and
nervous system deterioration. At this time, there is no known medication that will stop the …

The use of patient-derived induced pluripotent stem cells for Alzheimer's disease modeling

C Lee, SM Willerth, HB Nygaard - Progress in neurobiology, 2020 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by a
progressive deterioration in multiple facets of cognitive function. As the average age of the …

Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases

T Julia - Neuroscience letters, 2019 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by β-
amyloid (Aβ) plaques and neurofibrillary tangles with progressive cognitive decline. After …

Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives

LM Tong, H Fong, Y Huang - Experimental & molecular medicine, 2015 - nature.com
Underlying cognitive declines in Alzheimer's disease (AD) are the result of neuron and
neuronal process losses due to a wide range of factors. To date, all efforts to develop …

Important advances in Alzheimer's disease from the use of induced pluripotent stem cells

F Majolo, DR Marinowic, DC Machado… - Journal of biomedical …, 2019 - Springer
Among the various types of dementia, Alzheimer's disease (AD) is the most prevalent and is
clinically defined as the appearance of progressive deficits in cognition and memory …

Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy

J Yang, S Li, XB He, C Cheng, W Le - Molecular neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is the most common cause of dementia in those over the age of
65. While a numerous of disease-causing genes and risk factors have been identified, the …

Stem‐cell challenges in the treatment of Alzheimer's disease: a long way from bench to bedside

X Fan, D Sun, X Tang, Y Cai, ZQ Yin… - Medicinal research …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent type of dementia, and its neuropathology is
characterized by deposition of insoluble β‐amyloid peptides, intracellular neurofibrillary …

The application of patient-derived induced pluripotent stem cells for modeling and treatment of Alzheimer's disease

F Han, C Liu, J Huang, J Chen, C Wei… - Brain Science …, 2019 - journals.sagepub.com
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease
which is mainly caused by aggregated protein plaques in degenerating neurons of the brain …

Stem cell therapy for Alzheimer's disease

F Han, J Bi, L Qiao, O Arancio - Stem Cell-based Therapy for …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease caused by
eventually aggregated amyloid β (Aβ) plaques in degenerating neurons of the aging brain …