Cytokines are necessary for cell communication to enable responses to external stimuli that
are imperative for the survival and maintenance of homeostasis. Dysfunction of the cytokine …

Cytokines and growth factors regulate cell proliferation, differentiation, migration and
apoptosis, and play important roles in coordinating growth signal responses during …

The AU-rich elements (AREs) are among the predominant cis-acting factors that exist
primarily in the 3'untranslated region (3'-UTR) of messenger RNAs (mRNAs) and regulate …

The biosynthesis of inflammatory mediators relies on controlling the biogenesis and
utilization of their corresponding messenger RNAs (mRNAs). These latter “utilization steps” …

In this review we discuss specific examples of regulation of cytokine genes and focus on a
new mechanism involving post-transcriptional regulation via miRNAs. The post …

In mammalian somatic cells, the post-transcriptional control of cytokine or proto-oncogene
expression is often achieved by factors binding to sequence elements in the 3 …

Engagement of many types of cellular receptors initiates a signalling cascade that
converges on the nucleus, where transcription factors regulate expression of genes that …

In response to environmental signals, kinases phosphorylate numerous proteins, including
RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich …

Defects in AU-rich elements (ARE)-mediated posttranscriptional control can lead to several
abnormal processes that underlie carcinogenesis. Here, we performed a systematic analysis …

Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation
of inflammation-related genes, as well as for oncogene and tumor suppressor expression in …