Nel nuovo panorama delle immunoterapie, il microambiente locale del melanoma necessita
di essere esplorato e chiarito allo scopo di identificare marcatori predittivi di risposta. Infatti …

Immune-based therapies have achieved long term survival in metastatic melanoma, but
checkpoint inhibitors as monotherapy yield response rates between 15-40% 1, 2, 3. Low …

Background: An in situ “high resolution” investigation of the tumor microenvironment has
been urged in recent years by the previously failed attempt to find solid histological …

Introduction The complex spatial cellular interactions of immune cell populations within the
melanoma TIME are associated with patient prognosis and immunotherapy response. Novel …

The sentinel lymph node is the initial site of metastasis. Downregulation of antitumor
immunity has a role in nodal progression. Our objective was to investigate the relationship …

Tumor-infiltrating lymphocytes (TILs) are an important prognostic indicator in melanoma and
play a key role in the patient's response to immune checkpoint blockade. However, until …

Malignant melanoma is the most lethal form of skin cancer and its incidence has increased
drastically, with its clinical management lacking efficient options until recent years. The …

Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify
melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) …

There have been significant advances in the treatment of melanoma in the past several
years through the use of molecularly targeted therapy and immune checkpoint blockade …

Tumor-infiltrating immune cells have long been thought to affect tumor growth. In recent
years, large retrospective studies have shown that the nature and polarization of the immune …