Early detection of clinically significant prostate cancer at diagnosis: a prospective study using a novel panel of TMPRSS2:ETS fusion gene markers

SW Chan, PN Nguyen, P Violette, F Brimo… - Cancer …, 2013 - Wiley Online Library
We explore noninvasive clinical applications of multiple disease‐specific fusion markers
recently discovered in prostate cancer to predict the risk of cancer occurrence and …

TMPRSS2-ERG Fusion Transcripts in Matched Urine and Needle Rinse Material after Biopsy for the Detection of Prostate Cancer

PN Bories, P Younes, M Zerbib, L Denjean… - Clinical …, 2013 - academic.oup.com
BACKGROUND Current methods for detecting TMPRSS2-ERG fusion transcript in the urine
of patients with suspected prostate cancer lack diagnostic sensitivity. We combined urine …

TMPRSS2–ERG fusion transcripts expression in patients referred for prostate biopsy: combining detection in urine and needle rinse material

NB Delongchamps, P Younes, L Denjean… - World journal of …, 2015 - Springer
Objectives The objective of this study was to combine urine and prostate biopsy rinse
material (BRM) assays to increase sensitivity for fusion gene detection. Patients and …

A panel of TMPRSS2: ERG fusion transcript markers for urine-based prostate cancer detection with high specificity and sensitivity

PN Nguyen, P Violette, S Chan, S Tanguay, W Kassouf… - European urology, 2011 - Elsevier
BACKGROUND: The TMPRSS2: ERG fusion is both prevalent and unique to prostate cancer
(PCa) and has great potential for noninvasive diagnosis of PCa in bodily fluids …

Performance of a Single Assay for Both Type III and Type VI TMPRSS2:ERG Fusions in Noninvasive Prediction of Prostate Biopsy Outcome

JP Clark, KW Munson, JW Gu… - Clinical …, 2008 - academic.oup.com
Background: TMPRSS2: ERG fusions are promising prostate cancer biomarkers. Because
they can occur in multiple forms in a single cancer specimen, we developed a quantitative …

Prospective multicentre evaluation of PCA3 and TMPRSS2-ERG gene fusions as diagnostic and prognostic urinary biomarkers for prostate cancer

GHJM Leyten, D Hessels, SA Jannink, FP Smit… - European urology, 2014 - Elsevier
Background Prostate cancer antigen 3 (PCA3) and v-ets erythroblastosis virus E26
oncogene homolog (TMPRSS2-ERG) gene fusions are promising prostate cancer (PCa) …

[HTML][HTML] Prostate cancer detection and prognosis: from prostate specific antigen (PSA) to exosomal biomarkers

X Filella, L Foj - International journal of molecular sciences, 2016 - mdpi.com
Prostate specific antigen (PSA) remains the most used biomarker in the management of
early prostate cancer (PCa), in spite of the problems related to false positive results and …

[HTML][HTML] Prostate cancer biomarkers: are we hitting the mark?

S McGrath, D Christidis, M Perera, SK Hong… - Prostate …, 2016 - Elsevier
Purpose Localised prostate cancer diagnosis and management is increasingly complex due
to its heterogeneous progression and prognostic subgroups. Pitfalls in current screening …

Rational basis for the combination of PCA3 and TMPRSS2: ERG gene fusion for prostate cancer diagnosis

G Robert, S Jannink, F Smit, T Aalders, D Hessels… - The …, 2013 - Wiley Online Library
BACKGROUND The prostate cancer gene 3 (PCA3) and TMPRSS2: ERG gene fusion are
promising prostate cancer (PCa) specific biomarkers. Our aim was to simultaneously …

Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer

D Hessels, FP Smit, GW Verhaegh, JA Witjes… - Clinical Cancer …, 2007 - AACR
Purpose: Early detection of prostate cancer can increase the curative success rate for
prostate cancer. We studied the diagnostic usefulness of TMPRSS2-ERG fusion transcripts …