An overview of the background for proteomics and a description of the present state of art
are given with a description of the main strategies in proteomics. The advantages and …

Proteins are reckoned to be the key actors in a living organism. By studying proteins, one
engages into deciphering a complex series of events occurring during a protein's life span …

In recent years the array of mass spectrometry (MS) applications to address questions in
molecular and cellular biology has greatly expanded and continues to grow. Modern mass …

Mass spectrometry-based proteomics has become an essential part of the analytical toolbox
of the life sciences. With the ability to identify and quantify hundreds to thousands of proteins …

Proteomics became a key tool for the study of biological systems. The comparison between
two different physiological states allows unravelling the cellular and molecular mechanisms …

Conventional proteomics makes use of two-dimensional gel electrophoresis followed by
mass spectrometric analysis of tryptic fragments derived from in-gel digestion of proteins …

A newcomer to the-omics era, proteomics, is a broad instrument-intensive research area that
has advanced rapidly since its inception less than 20 years ago. Although the 'wet …

This review provides an introduction for the nonspecialist to proteomics and in particular the
major approaches available for global protein identification and quantification. Proteomics …

In this chapter, the evolvement of proteomics from classical protein chemistry is depicted.
The challenges of complexity and dynamics led to several new approaches and to the firm …

Publisher Summary The chapter focuses on the tools used in proteomics. Mass spectrometry
(MS)-based methods have become the primary technology used to identify proteins. The …