Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system

DL Rosin, A Robeva, RL Woodard… - Journal of …, 1998 - Wiley Online Library
The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …

Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum

BD Hettinger, A Lee, J Linden… - Journal of Comparative …, 2001 - Wiley Online Library
Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …

Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease

K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals… - Neurology, 2003 - AAN Enterprises
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …

Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice

LV Lopes, L Halldner, N Rebola… - British journal of …, 2004 - Wiley Online Library
2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …

Adenosine A2A receptors and basal ganglia physiology

SN Schiffmann, G Fisone, R Moresco, RA Cunha… - Progress in …, 2007 - Elsevier
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders

RA Cunha, S Ferré, JM Vaugeois… - Current pharmaceutical …, 2008 - ingentaconnect.com
The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

MI Martinez-Mir, A Probst, JM Palacios - Neuroscience, 1991 - Elsevier
Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections
of the human brain using the A2-selective agonist ligand [3 H](2-p-(2-car☐ yethyl) …

Binding of the Adenosine A2 Receptor Ligand [3H]CGS 21680 to Human and Rat Brain: Evidence for Multiple Affinity Sites

W Wan, GR Sutherland, JD Geiger - Journal of neurochemistry, 1990 - Wiley Online Library
A new radiolabeled adenosine receptor agonist, 2‐[p‐(2‐carboxyethyl) phenethylamino]‐
5′‐. N‐ethylcarboxamidoadenosine (CGS 21680), apparently specific for high‐affinity …

Distribution of adenosine A2 receptor mRNA in the human brain

SN Schiffmann, F Libert, G Vassart… - Neuroscience …, 1991 - Elsevier
The distribution of the messenger RNA coding for the recently cloned adenosine A 2
receptor was studied in the human brain using in situ hybridization histochemistry. A 2 …

Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and …

SA Rivkees, SL Price, FC Zhou - Brain research, 1995 - Elsevier
Polyclonal antisera were generated against two identical regions of rat and human A1
adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western …