In adult rat brain, adenosine A2A receptors and dopamine D2 receptors are known to be
located on the same cells where they interact in an antagonistic manner. In the present study …

Many of our current hopes of finding better ways to treat Parkinson's disease or to stop its
progression rely on studies of adenosine A2A receptors in the brain. Yet any drug targeting …

To clarify differences in the operating mechanisms of adenosine receptor subtypes (A1 and
A2), striatal extracellular dopamine levels under various conditions were determined by in …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

The A1 adenosine receptor is the best characterized of the widely distributed purinergic
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …

The influence of the adenosine A2A receptor on the A1 receptor was examined in rat striatal
nerve terminals, a model for other cells in which these receptors are coexpressed …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

The adenosine A2A receptor subtype is one of the four adenosine receptors that have been
identified in the mammalian organism. In addition to being found in blood vessels, platelets …