Evaluation of adenosine A2 receptor function in the mammalian CNS has been impeded by
the lack ofhighly selective A2 receptor agonists. The present investigations describe the …

The results presented in this paper show that adenosine A2A receptor (A2AR) form
homodimers and that homodimers but not monomers are the functional species at the cell …

A3 Adenosine receptors (ARs) exhibit large species differences. Potent, selective agonists
for rat (eg Cl-IB-MECA, 5) and human A3 ARs (eg PENECA, 17, and analogs) have been …

The adenosine A3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

Adenosine's effects result from a balanced activation of inhibitory A1 and facilitatory A2A
receptors. Because in aged animals there is an increased number of A2A receptors, we now …

The anti‐Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine
A2A receptor antagonists is believed to result from their ability to postsynaptically control the …

The actions of the neurotransmitter adenosine are mediated by a family of high‐affinity, G
protein‐coupled receptors. We have characterized the gene for the human A2a subtype of …

The effect of oral treatment with caffeine, in doses that are known to produce marked
adaptive effects, was investigated on A1 and A2A receptors in the mouse brain. Caffeine …

A cDNA encoding a G protein-coupled receptor of unknown ligand specificity was isolated
from a human hippocampal cDNA library by virtue of the high degree of structural homology …

The selective localization of adenosine A2A receptors to the striatopallidal system
suggested a new therapeutic approach to the management of Parkinson's disease (PD). The …