We have characterized the in vitro pharmacological profile of the new potent and selective
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …

Adenosine's diverse physiological functions are mediated by four subtypes of receptors (A1,
A2A, A2B and A3). The A1 adenosine receptor pharmacology and therapeutic application of …

Antagonism of the human A2A receptor has been implicated as a point of therapeutic
intervention in the alleviation of the symptoms associated with Parkinson's disease. This is …

Adenosine A2A receptors have a unique cellular and regional distribution in the basal
ganglia, being particularly concentrated in areas richly innervated by dopamine such as the …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that regulates
several important functions in the central nervous system. Large amount of preclinical data …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that stimulates
adenylyl cyclase activity. In the brain, A 2A Rs are found highly enriched in striatal …

Antagonists of adenosine A 2A receptors (A 2A-antagonists) with different chemical
structures have been developed by several pharmaceutical companies for the potential …

Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons
(MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D2 …

The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …