In this study, in order to investigate the p53-independent function of p14ARF, we established
p14ARF-inducible clones in the p53-deficient HCT cell line using the doxycycline-inducible …

While p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the
mechanism by which p14ARF inhibits tumorigenesis independently of p53 remains elusive …

Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …

Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …

The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …

Alterations in the ARF tumour suppressor protein (also known as p14ARF in humans and
p19ARF in the mouse) occur frequently in cancer and are associated with susceptibility to …

Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …

The ARF tumor suppressor participates in a p53-dependent apoptotic pathway that is
stimulated in response to some oncogenic stimuli. The E2F1 transcription factor is a critical …

The ARF tumour suppressor protein (p14 ARF in human and p19 ARF in mouse) is a major
mediator of the activation of p53 in response to oncogenic stress. Little is known about the …

The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …