Osteocytes are the main sensitive cells in bone remodeling due to their potent functional cell
processes from the mineralized bone matrix to the bone surface and the bone marrow …

Gap junctions, which are mainly composed of connexin units, play an indispensable role in
cell morphogenesis, proliferation, migration, adhesion and differentiation of osteoblast …

Background Gap junction intercellular communication (GJIC) plays an important role in cell
growth, development and homeostasis. Connexin 43 (Cx43) is an important half-channel …

Platelet‑derived growth factor‑BB (PDGF‑BB) serves a critical function in human osteoblast
differentiation and proliferation. Src and Janus kinase 2 (JAK2) are involved in these …

Mechanical stimulation can prompt healing of bone fractures. However, it is largely unknown
how osteogenesis is promoted by mechanical stimulation. In this study, we found that …

The physiological functions of platelet‐derived growth factor receptors (PDGFRs) α and β in
osteoblast biology and bone metabolism remain to be established. Here, we show that …

Enhanced osteoclast formation increases bone resorption, which triggers bone remodeling.
Platelet-derived growth factor BB (PDGF-BB) enhances precursor cell homing …

Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β
(PDGFR-β) pathway is conventionally considered as an important pathway to promote …

We previously showed that exogenous insulin-like growth factor-I (IGF-I) and bone
morphogenetic protein-7 (BMP-7) synergistically stimulated osteoblast differentiation in fetal …

Bone has the capacity for repair and regeneration. The repair process is thought to be
locally regulated by growth factors. One of the growth factors that potentially plays a …