Perspectives in organ preservation

MHJ Maathuis, HGD Leuvenink, RJ Ploeg - Transplantation, 2007 - journals.lww.com
Maintaining organ viability after donation until transplantation is critically important for
optimal graft function and survival. To date, static cold storage is the most widely used form …

The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury

T Vogel, JG Brockmann, C Coussios, PJ Friend - Transplantation reviews, 2012 - Elsevier
The primary objective of organ preservation is to deliver a viable graft with minimal risk of
impaired postoperative graft function. In current clinical practice, preservation of transplanted …

Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives

X Yuan, AJ Theruvath, X Ge… - Transplant …, 2010 - Wiley Online Library
Most organs are currently preserved by cold storage (CS) prior to transplantation. However,
as more so called marginal donor organs are utilized, machine perfusion has regained …

Organ preservation: current concepts and new strategies for the next decade

EE Guibert, AY Petrenko, CL Balaban… - Transfusion Medicine …, 2011 - karger.com
Organ transplantation has developed over the past 50 years to reach the sophisticated and
integrated clinical service of today through several advances in science. One of the most …

Organ preservation: from the past to the future

L Jing, L Yao, M Zhao, L Peng, M Liu - Acta Pharmacologica Sinica, 2018 - nature.com
Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …

The future of organ perfusion and re‐conditioning

A Weissenbacher, G Vrakas, D Nasralla… - Transplant …, 2019 - Wiley Online Library
Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

Normothermic liver preservation: a new paradigm?

R Ravikumar, H Leuvenink… - Transplant international, 2015 - Wiley Online Library
Despite increasing donor numbers, waiting lists and pre‐transplant mortality continue to
grow in many countries. The number of donor organs suitable for liver transplantation is …

Machine perfusion of donor organs for transplantation

R Tatum, TJ O'Malley, AS Bodzin… - Artificial …, 2021 - Wiley Online Library
The ever‐widening gap between organ supply and demand has resulted in an organ
shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) …

Current state of hypothermic machine perfusion preservation of organs: The clinical perspective

MJ Taylor, SC Baicu - Cryobiology, 2010 - Elsevier
This review focuses on the application of hypothermic perfusion technology as a topic of
current interest with the potential to have a salutary impact on the mounting clinical …

Hypothermic perfusion preservation: the future of organ preservation revisited?

BJ Fuller, CY Lee - Cryobiology, 2007 - Elsevier
Hypothermic perfusion preservation (HPP) was an integral step in the development of early
clinical transplantation programmes, and considerable progress was made in understanding …