A fundamental hallmark of cancer is the cell's ability to sustain proliferative signaling thereby
deregulating the cell cycle. Uncovering the molecular changes that inappropriately drive …

Background: Head and neck squamous cell carcinoma (HNSCC) remains a challenging
prevalent lethal malignancy, with still scarce targeted therapies and rather limited clinical …

CELL CYCLE PROGRESSION Progression of cells through the cell cycle is dependent on
the formation of specific protein kinase complexes which form in a cyclical fashion at …

Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …

Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising
that the deregulation of the cell cycle is one of the most frequent alterations during tumor …

Oral squamous cell carcinoma (OSCC) is a major global health problem with a relatively low‐
moderate 5‐year survival rate. OSCC is often preceded by lesions and conditions known as …

Regulated cell division is one of the fundamental phenomena which is the basis of all life on
earth. Even a single base pair mutation in DNA leads to the production of the dysregulated …

Cellular growth, development, and differentiation are tightly controlled by a conserved
biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent …

Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …

Progression through each phase of the cell division cycle is driven by specific cyclin/CDK
holoenzymes complexes, each complex having a discrete subset of critical substrates …