[HTML][HTML] Engineered tolerance: tailoring development, function, and antigen-specificity of regulatory T cells

NAJ Dawson, J Vent-Schmidt, MK Levings - Frontiers in immunology, 2017 - frontiersin.org
Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently
being clinically tested for their potential to stop or control undesired immune responses in …

[HTML][HTML] Engineering specificity and function of therapeutic regulatory T cells

JL McGovern, GP Wright, HJ Stauss - Frontiers in Immunology, 2017 - frontiersin.org
Adoptive therapy with polyclonal regulatory T cells (Tregs) has shown efficacy in
suppressing detrimental immune responses in experimental models of autoimmunity and …

[HTML][HTML] Therapeutic potential of gene-modified regulatory T cells: from bench to bedside

WJ Chae, ALM Bothwell - Frontiers in Immunology, 2018 - frontiersin.org
Regulatory T cells (Tregs) are an important subset of adaptive immune cells and control
immune reactions for maintaining homeostasis. Tregs are generated upon their encounter …

Harnessing regulatory T cells to establish immune tolerance

P Ho, E Cahir-McFarland, JD Fontenot… - Science Translational …, 2024 - science.org
Engineered regulatory T (Treg) cells have emerged as precision therapeutics aimed at
inducing immune tolerance while reducing the risks associated with generalized …

[HTML][HTML] Super-Treg: toward a new era of adoptive Treg therapy enabled by genetic modifications

L Amini, J Greig, M Schmueck-Henneresse… - Frontiers in …, 2021 - frontiersin.org
Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis.
Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in …

Eras of designer Tregs: Harnessing synthetic biology for immune suppression

K Tuomela, K Salim, MK Levings - Immunological Reviews, 2023 - Wiley Online Library
Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

[HTML][HTML] Unlocking the potential of Tregs: innovations in CAR technology

CJ Requejo Cier, N Valentini… - Frontiers in Molecular …, 2023 - frontiersin.org
Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option
for both autoimmune and alloimmune diseases. However, numerous challenges remain …

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

JA Bluestone, E Trotta, D Xu - Expert opinion on therapeutic targets, 2015 - Taylor & Francis
Introduction: Immune tolerance remains the holy grail of therapeutic immunology in the fields
of organ and tissue transplant rejection, autoimmune diseases, and allergy and asthma. We …

Harnessing advances in T regulatory cell biology for cellular therapy in transplantation

AJ Lam, RE Hoeppli, MK Levings - Transplantation, 2017 - journals.lww.com
Cellular therapy with CD4+FOXP3+ T regulatory (Treg) cells is a promising strategy to
induce tolerance after solidorgan transplantation or prevent graft-versus-host disease after …

Regulatory T cells: customizing for the clinic

X Wang, L Lu, S Jiang - Science translational medicine, 2011 - science.org
Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific
regulatory T cells (Treg cells), lymphocytes that suppress certain immune responses …