The failure of mammalian CNS neurons to regenerate their axons derives from a
combination of intrinsic deficits and extrinsic obstacles. Following injury, chondroitin sulfate …

Axons in the peripheral nervous system can regenerate after injury, whereas axons in the
central nervous system (CNS) do not readily regenerate. Intrinsic regenerating capacity and …

We examined whether enzymatic digestion of chondroitin sulfate (CS) promoted the axonal
regeneration of neurons in Clarke's nucleus (CN) into a peripheral nerve (PN) graft following …

The study of chondroitin sulfate (CS) and related proteoglycan (PG) structure and function
has significantly influenced our understanding of a wide variety of biological processes and …

The glycosaminoglycan chondroitin sulfate (CS) is a major constituent of the extracellular
matrix of the central nervous system where it can constitute part of the perineuronal nets …

Organized cultures of mouse dorsal root ganglia (PNS), cerebellum (CNS), and sympathetic
chain ganglia (ANS) were exposed to feeding media containing radioactive Na235SO4 for …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Chondroitin sulphate proteoglycans (CSPGs) upregulated at sites of nerve injury restrict
axonal regrowth and hamper nerve regeneration. Digestion of the CS moieties in vivo with …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Nerve regeneration after brain or spinal cord injury can be improved by dissolving the sugar
chains found on the inhibitory protein molecules that fill the scar tissue. Neuroscientists at …