Potential nanocarriers of chondroitinase for the treatment of spinal cord injury
Y Park - 한국당과학회학술대회, 2008 - earticle.net
Recent studies have shown the potential therapeutic uses of chondroitinase to recover loss
of function in spinal cord injuries by regenerating neuronal growth. Upon injury to the spinal …
of function in spinal cord injuries by regenerating neuronal growth. Upon injury to the spinal …
6-Sulphated chondroitins have a positive influence on axonal regeneration
R Lin, TW Rosahl, PJ Whiting, JW Fawcett, JCF Kwok - PloS one, 2011 - journals.plos.org
Chondroitin sulphate proteoglycans (CSPGs) upregulated in the glial scar inhibit axon
regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6 …
regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6 …
Sulfated glycans in network rewiring and plasticity after neuronal injuries
K Kadomatsu, K Sakamoto - Neuroscience Research, 2014 - Elsevier
Biopolymers in the human body belong to three major classes: polynucleotides (DNA, RNA),
polypeptides (proteins) and polysaccharides (glycans). Although striking progress in our …
polypeptides (proteins) and polysaccharides (glycans). Although striking progress in our …
Reduction of Chondroitin Sulfate Proteoglycans to Increase Axonal Outgrowth In a Neuronal Co-Culture Model
HM Tuinstra, CS Amy, LD Shea - The 2008 Annual Meeting, 2008 - aiche.confex.com
Regeneration after spinal cord injury is limited in part by an environment that inhibits axonal
outgrowth, and overcoming this barrier is a necessary step. In particular, deposition of an …
outgrowth, and overcoming this barrier is a necessary step. In particular, deposition of an …
[引用][C] Modulation of CSPG sulfation patterns through siRNA silencing of sulfotransferase expression to promote CNS regeneration
MA Millner - 2008
The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes
JR Siebert, DJ Osterhout - Journal of neurochemistry, 2011 - Wiley Online Library
J. Neurochem.(2011) 119, 176–188. Abstract The formation of the glial scar following a
spinal cord injury presents a significant barrier to the regenerative process. It is primarily …
spinal cord injury presents a significant barrier to the regenerative process. It is primarily …
Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after …
T Iseda, T Okuda, N Kane-Goldsmith… - Journal of …, 2008 - liebertpub.com
Chondroitin sulfate proteoglycans (CSPGs) inhibit axonal growth, and treatment with
chondroitinase ABC promotes axonal regeneration in some models of central nervous …
chondroitinase ABC promotes axonal regeneration in some models of central nervous …
Chondroitin sulfate glycosaminoglycans for CNS homeostasis-implications for material design
Chondroitin sulfate proteoglycans (CSPGs) are complex biomolecules that are known to
facilitate patterning of axonal direction and cell migration during the early growth and …
facilitate patterning of axonal direction and cell migration during the early growth and …
[引用][C] Chondroitinase ABC promotes spinal cord regeneration
EJ Bradbury - Inpharma, 2002 - Springer
In this study, animals with a C4 dorsal column crush lesion were administered intrathecal
chondroitinase ABC or placebo. Animals administered chondroitinase ABC, but not those …
chondroitinase ABC or placebo. Animals administered chondroitinase ABC, but not those …
Chemoenzymatic preparation of chondroitin sulfates with a defined sulfation pattern
It is known that the proteoglycans present in the extracellular matrix, promote growth and
differentiation of neural cells during development and maturation of the central nervous …
differentiation of neural cells during development and maturation of the central nervous …