A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation‐associated neurodegeneration

A Rolls, L Cahalon, S Bakalash, H Avidan… - The FASEB …, 2006 - Wiley Online Library
Chondroitin sulfate proteoglycan (CSPG), a matrix protein that occurs naturally in the central
nervous system (CNS), is considered to be a major inhibitor of axonal regeneration and is …

Keratan sulfate restricts neural plasticity after spinal cord injury

S Imagama, K Sakamoto, R Tauchi… - Journal of …, 2011 - Soc Neuroscience
Chondroitin sulfate (CS) proteoglycans are strong inhibitors of structural rearrangement after
injuries of the adult CNS. In addition to CS chains, keratan sulfate (KS) chains are also …

The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slices

A Schurr, CA West, MF Heine, BM Rigor - Brain research, 1993 - Elsevier
The rat hippocampal slice preparation and its electrophysiology were used to assess the
toxicity of two sulfur-containing amino acids, l-cysteate (CA) and l-cysteine (CYS). Both …

Chondroitin sulfate proteoglycans in the brain

S Aono, A Oohira - Advances in Pharmacology, 2006 - Elsevier
Publisher Summary Chondroitin sulfate proteoglycans (CSPGs) play important roles in the
morphogenesis and maintenance of various tissues, including the central nervous system …

Identification and functions of chondroitin sulfate in the milieu of neural stem cells

M Ida, T Shuo, K Hirano, Y Tokita, K Nakanishi… - Journal of biological …, 2006 - ASBMB
The behavior of cells is generally considered to be regulated by environmental factors, but
the molecules in the milieu of neural stem cells have been little studied. We found by …

Decoding the Structure‐Activity Relationships of Glycosaminoglycans in the Brain

LC Hsieh‐Wilson - 2006 - Wiley Online Library
Our research integrates organic chemistry with neurobiology to explore molecular
mechanisms of neuronal communication in the brain. In particular, we are interested in …

Overcoming the chondroitin sulphate barrier in injured nerve: the efficacy of chondroitinase ABC treatment and the potency of disaccharide products

KW Tam, YS Chan, DKY Shum - International Symposium on Healthy …, 2014 - hub.hku.hk
Chondroitin sulphate proteoglycans (CSPGs) up-regulated in the extracellular matrix of
injured nerves, constitute barriers to nerve regeneration. Cleavage of CS using …

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

AM Clement, K Sugahara, A Faissner - Neuroscience letters, 1999 - Elsevier
In light of controversial reports concerning the effects of chondroitin sulfates on neurite
outgrowth, several glycosaminoglycans belonging to this structural class were compared …

Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage

Y Xiong, DQ Xin, Q Hu, LX Wang, J Qiu… - Neural Regeneration …, 2020 - journals.lww.com
Hydrogen sulfide, which can be generated in the central nervous system from the sulfhydryl-
containing amino acid, L-cysteine, by cystathionine-β-synthase, may exert protective effects …

[引用][C] From hard to soft: a journey of chondroitin sulphate proteoglycans (CSPGs) in the regeneration and plasticity of the nervous system