Chondroitin sulfate proteoglycans (CSPGs) is one kind of proteins that covalently bind with
chondroitin sulfate. CSPGs play important roles in the growth and development of the central …

The beneficial effect of interventions with chondroitinase ABC enzyme to reduce axon
growth-inhibitory chondroitin sulphate side chains after central nervous system injuries has …

Background: Chondroitin sulfate glycosaminoglycans (CS-GAGs) are the primary inhibitory
GAGs for neuronal growth after central nervous system (CNS) injury. However, the inhibitory …

Chondroitin sulfate proteoglycan (CSPG) is a group of extracellular matrix molecules
expressed widely in the developing and mature central nervous system (CNS). They play an …

Increased intracranial pressure (ICP) caused by edema following severe traumatic brain
injury (TBI) or stroke contributes to high rates of mortality and morbidity. The search …

Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral
infection to neuroregeneration. Their regiospecific sulfation patterns, which are generated by …

Publisher Summary Increased levels of chondroitin sulfate proteoglycan (CSPG)
characterize responses to various types of tissue injury both in the periphery and in the …

Statins elicit numerous favorable effects on central nervous system (CNS) injury, including
inhibition of the rhoA/ROCK pathway. In the present study, we show that statins decrease …

Chondroitin sulphate proteoglycans (CSPGs) are up‐regulated in the CNS after injury and
inhibit axon regeneration mainly through their glycosaminoglycan (CS‐GAG) chains. We …

The presence of numerous axon-inhibitory molecules limits the capacity of injured neurons
in the adult mammalian central nervous system (CNS) to regenerate damaged axons …