Inhibitory extracellular matrices form around mature neurons as perineuronal nets
containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The …

Chondroitin sulphate (CS) proteoglycans are up-regulated in the extracellular matrix of
injured nerves and constitute barriers to axonal re-growth. Chondroitin sulphate ABC lyases …

Several factors contribute to the lack of repair following spinal cord injury, such as the lack of
growth-promoting factors, poor intrinsic central nervous system regeneration abilities, and …

抄録 多硫酸化コンドロイチン硫酸 (CS) には CS-D, CS-E, CS-H および CS-K があり,
いずれもジ硫酸化あるいはトリ硫酸化二糖単位を構成単位として含むという特徴があり …

Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory
chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration …

0002 Ischemic brain disease such as thrombotic cerebral infarction or embolic cerebral
infarction, which is cerebral stroke known as one of three major causes of death in Japan …

Neurodegeneration is caused by the progressive loss of the structure and function of
neurons, leading to cell death, and it is the main cause of many neurodegenerative …

Cysteine and its metabolites cysteine sulphinic acid (CSA) and taurine (TA) were shown to
be toxic to human and rat neuronal cell lines. However, the mechanisms of action of CSA …

Neurons in the adult CNS do not spontaneously regenerate after injuries. The
glycosaminoglycan keratan sulfate is induced after spinal cord injury, but its biological …

Objectives: Currently, effective therapeutic strategy for spinal cord injury (SCI) is not clinically
available. To establish a better method that may help repair the injured spinal cord, sodium …