Alcoholism and psychiatric disorders like depression and anxiety are often comorbid.
Although the mechanisms underlying this comorbidity are unclear, emerging evidence …

The lateral habenula (LHb) is activated by a range of aversive states including those related
to alcohol withdrawal and has glycine receptors (GlyRs), a sensitive target of alcohol …

Recent studies show that neuron-glial communication plays an important role in
neurological diseases. Particularly, dysfunction of astroglial glutamate transporter GLT-1 has …

The lateral habenula (LHb) regulates the activity of monoaminergic neurons in the
brainstem. This area has recently attracted a surge of interest in psychiatry because studies …

Alcohol use disorder (AUD) or alcoholism is a chronic relapsing disorder. Our knowledge of
alcoholism hinges on our understanding of its effects on the brain. This review will center on …

A hyperglutamatergic state has been hypothesized to drive escalation of alcohol intake. This
hypothesis predicts that an impairment of glutamate clearance through inactivation of the …

Alcohol use disorders (AUDs) and anxiety disorders (ADs) are often seen concurrently, but
their underlying cellular basis is unclear. For unclear reasons, the lateral habenula (LHb), a …

The hyperactivity of the lateral habenula (LHb) is closely associated with depression. At
present, it is unknown how GABA transporter (GAT) in the LHb affects depressive-like …

Depression is a well-known risk factor for developing relapse drinking, but the neuronal
mechanisms underlying the interactions between depression and alcohol use disorders …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …