Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

The klotho gene (KL) was identified first as a putative aging-suppressor gene that extended
life span when overexpressed and accelerated aging-like phenotypes when disrupted in …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Klotho is a single-pass transmembrane protein highly expressed in the kidney. Membrane
Klotho protein acts as a co-receptor for fibroblast growth factor-23. Its extracellular domain is …

Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease
patients undergoing dialysis with multiple accelerated age-related disorders, including …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney
and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …