The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

IL-6 activates various cell types carrying the membrane bound IL-6R (classical IL-6
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …

Interleukin (IL)-6 is a pro-inflammatory cytokine that produces multifunctional effects.
Deregulated IL-6 production and signaling are associated with chronic inflammatory …

Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …