The biology and medical implications of interleukin-6
T Tanaka, T Kishimoto - Cancer immunology research, 2014 - AACR
Cytokines are soluble mediators, which aid cell-to-cell communication in immune
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …
Interleukin-6 signaling pathway in targeted therapy for cancer
Y Guo, F Xu, TJ Lu, Z Duan, Z Zhang - Cancer treatment reviews, 2012 - Elsevier
Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …
Interleukin 6: from bench to bedside
N Nishimoto, T Kishimoto - Nature clinical practice Rheumatology, 2006 - nature.com
Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …
Gene of the month: Interleukin 6 (IL-6)
P Ataie-Kachoie, MH Pourgholami… - Journal of clinical …, 2014 - jcp.bmj.com
The Interleukin 6 (IL-6) gene encodes the classic proinflammatory cytokine IL-6. It is also
known as interferon-β2 (IFN-β2), B cell stimulatory factor-2 and hybridoma/plasmacytoma …
known as interferon-β2 (IFN-β2), B cell stimulatory factor-2 and hybridoma/plasmacytoma …
Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
The role of IL-7 and IL-7R in cancer pathophysiology and immunotherapy
C Wang, L Kong, S Kim, S Lee, S Oh, S Jo… - International journal of …, 2022 - mdpi.com
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …
Targeting IL-6 trans-signalling: past, present and future prospects
S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
Recent advances in underlying pathologies provide insight into interleukin‐8 expression‐mediated inflammation and angiogenesis
Interleukin‐8 has long been recognized to have anti‐inflammatory activity, which has been
established in various models of infection, inflammation, and cancer. Several cell types …
established in various models of infection, inflammation, and cancer. Several cell types …
Interleukin‐6 and its receptor in cancer: implications for translational therapeutics
DS Hong, LS Angelo, R Kurzrock - Cancer, 2007 - Wiley Online Library
Abstract Interleukin‐6 (IL‐6) plays a major role in the response to injury or infection and is
involved in the immune response, inflammation, and hematopoiesis. Its deregulation …
involved in the immune response, inflammation, and hematopoiesis. Its deregulation …