The biology and medical implications of interleukin-6

T Tanaka, T Kishimoto - Cancer immunology research, 2014 - AACR
Cytokines are soluble mediators, which aid cell-to-cell communication in immune
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …

Interleukin-6 signaling pathway in targeted therapy for cancer

Y Guo, F Xu, TJ Lu, Z Duan, Z Zhang - Cancer treatment reviews, 2012 - Elsevier
Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

Interleukin 6: from bench to bedside

N Nishimoto, T Kishimoto - Nature clinical practice Rheumatology, 2006 - nature.com
Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …

Gene of the month: Interleukin 6 (IL-6)

P Ataie-Kachoie, MH Pourgholami… - Journal of clinical …, 2014 - jcp.bmj.com
The Interleukin 6 (IL-6) gene encodes the classic proinflammatory cytokine IL-6. It is also
known as interferon-β2 (IFN-β2), B cell stimulatory factor-2 and hybridoma/plasmacytoma …

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

M Aliyu, FT Zohora, AU Anka, K Ali, S Maleknia… - International …, 2022 - Elsevier
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …

The role of IL-7 and IL-7R in cancer pathophysiology and immunotherapy

C Wang, L Kong, S Kim, S Lee, S Oh, S Jo… - International journal of …, 2022 - mdpi.com
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors

S Kaur, Y Bansal, R Kumar, G Bansal - Bioorganic & medicinal chemistry, 2020 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

Recent advances in underlying pathologies provide insight into interleukin‐8 expression‐mediated inflammation and angiogenesis

BS Qazi, K Tang, A Qazi - International journal of inflammation, 2011 - Wiley Online Library
Interleukin‐8 has long been recognized to have anti‐inflammatory activity, which has been
established in various models of infection, inflammation, and cancer. Several cell types …

Interleukin‐6 and its receptor in cancer: implications for translational therapeutics

DS Hong, LS Angelo, R Kurzrock - Cancer, 2007 - Wiley Online Library
Abstract Interleukin‐6 (IL‐6) plays a major role in the response to injury or infection and is
involved in the immune response, inflammation, and hematopoiesis. Its deregulation …