Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic rats

S Maeda, S Yamagishi, T Matsui, S Nakashima… - Ophthalmic …, 2013 - karger.com
Background/Aims: Vildagliptin is an oral inhibitor of dipeptidyl peptidase-4, an enzyme
mainly responsible for inactivating incretins, and one of the widely used drugs for the …

Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet

S Halimi, A Schweizer, B Minic, J Foley… - Vascular health and …, 2008 - Taylor & Francis
Vildagliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-4), orally
active, that improves glycemic control in patients with type 2 diabetes (T2DM) primarily by …

Multifactorial effects of vildagliptin added to ongoing metformin therapy in patients with type 2 diabetes mellitus

A Strózik, A Stęposz, M Basiak, M Drożdż… - Pharmacological …, 2015 - Springer
Background To assess the efficacy of a vildagliptin and metformin combination therapy to a
metformin monotherapy in type 2 diabetes mellitus patients. Methods: Sixty-one patients with …

The islet enhancer vildagliptin: mechanisms of improved glucose metabolism

B Ahrén, JE Foley - International Journal of Clinical Practice, 2008 - Wiley Online Library
Vildagliptin is a potent, selective and reversible inhibitor of dipeptidyl peptidase‐4 (DPP‐4),
the enzyme responsible for rapid inactivation of the incretin hormones glucagon‐like peptide …

The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus

G Kim, S Oh, SM Jin, KY Hur, JH Kim… - Expert Opinion on …, 2017 - Taylor & Francis
Objective: To compare the effects of either vildagliptin or glimepiride on glycemic variability,
oxidative stress, and endothelial parameters in patients with type 2 diabetes mellitus (T2DM) …

[PDF][PDF] Emerging role of dipeptidyl peptidase-IV (DPP-4) inhibitor vildagliptin in the management of type 2 diabetes

S Kalra - J Assoc Physicians India, 2011 - researchgate.net
Diabetes mellitus (DM) is one of the most common chronic disorders, with increasing
prevalence worldwide. Type 2 diabetes (T2DM), a multifaceted disease involving multiple …

Vildagliptin action on some adipocytokine levels in type 2 diabetic patients: a 12-month, placebo-controlled study

G Derosa, PD Ragonesi, A Carbone… - Expert opinion on …, 2012 - Taylor & Francis
Objective: To evaluate the action of vildagliptin+ metformin on some adipocytokine levels,
glycemic control, and β-cell function in type 2 diabetic patients. Research design and …

Vildagliptin: a new oral treatment for type 2 diabetes mellitus

C Mathieu, E Degrande - Vascular health and risk management, 2008 - Taylor & Francis
Vildagliptin is a new oral antidiabetic agent that enhances pancreatic islet cell
responsiveness to glucose. An extensive clinical program involving approximately 22,000 …

Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric-oxide synthase-dependent mechanism

M Ishii, R Shibata, K Kondo, T Kambara… - Journal of Biological …, 2014 - ASBMB
Dipeptidyl peptidase-4 inhibitors are known to lower glucose levels and are also beneficial
in the management of cardiovascular disease. Here, we investigated whether a dipeptidyl …

Vildagliptin: a review of its use in the management of type 2 diabetes mellitus

JD Croxtall, SJ Keam - Drugs, 2008 - Springer
Vildagliptin (Galvus®) is an antihyperglycaemic agent that selectively inhibits the dipeptidyl
peptidase-4 (DPP-4) enzyme. Such inhibition prevents the degradation of the incretin …