Challenges in realizing selectivity for nanoparticle biodistribution and clearance: lessons from gold nanoparticles
The field of nanomedicine has received much attention for its potential to allow for targeted
identification and treatment of tumors, while sparing healthy tissue. This promise has yet to …
identification and treatment of tumors, while sparing healthy tissue. This promise has yet to …
Tailoring renal clearance and tumor targeting of ultrasmall metal nanoparticles with particle density
Identifying key factors that govern the in vivo behavior of nanomaterials is critical to the
clinical translation of nanomedicines. Overshadowed by size‐, shape‐, and surface …
clinical translation of nanomedicines. Overshadowed by size‐, shape‐, and surface …
Biocompatibility, uptake and endocytosis pathways of polystyrene nanoparticles in primary human renal epithelial cells
Recent years have witnessed an unprecedented growth in the number of applications–such
as drug delivery, nutraceuticals and production of improved biocompatible materials–in the …
as drug delivery, nutraceuticals and production of improved biocompatible materials–in the …
Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake: Relevance for drug delivery systems
R Firdessa, TA Oelschlaeger, H Moll - European journal of cell biology, 2014 - Elsevier
Nanoparticles may address challenges by human diseases through improving diagnosis,
vaccination and treatment. The uptake mechanism regulates the type of threat a particle …
vaccination and treatment. The uptake mechanism regulates the type of threat a particle …
Mechanism of hard-nanomaterial clearance by the liver
KM Tsoi, SA MacParland, XZ Ma, VN Spetzler… - Nature materials, 2016 - nature.com
The liver and spleen are major biological barriers to translating nanomedicines because
they sequester the majority of administered nanomaterials and prevent delivery to diseased …
they sequester the majority of administered nanomaterials and prevent delivery to diseased …
Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance
Before researchers apply nanomaterials (NMs) in biomedicine, they need to understand the
blood circulation and clearance profile of these materials in vivo. These qualities determine …
blood circulation and clearance profile of these materials in vivo. These qualities determine …
Insight into cellular uptake and intracellular trafficking of nanoparticles
P Foroozandeh, AA Aziz - Nanoscale research letters, 2018 - Springer
Nanoparticle science is rapidly changing the landscape of various scientific fields and
defining new technological platforms. This is perhaps even more evident in the field of …
defining new technological platforms. This is perhaps even more evident in the field of …
[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
Limits and challenges in using transport inhibitors to characterize how nano-sized drug carriers enter cells
Aim: In this work we illustrate limits and challenges associated with the use of
pharmacological inhibitors to study how nanomedicines enter cells and show how such …
pharmacological inhibitors to study how nanomedicines enter cells and show how such …
Physical chemistry of nanomedicine: understanding the complex behaviors of nanoparticles in vivo
Nanomedicine is an interdisciplinary field of research at the interface of science,
engineering, and medicine, with broad clinical applications ranging from molecular imaging …
engineering, and medicine, with broad clinical applications ranging from molecular imaging …