Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization

PJ Smith, M Giroud, HL Wiggins, F Gower… - International journal …, 2012 - Taylor & Francis
Increasing production and application of nanomaterials raises significant questions
regarding the potential for cellular entry and toxicity of nanoparticles. It was observed that …

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier

A Beloqui, A des Rieux, V Préat - Advanced drug delivery reviews, 2016 - Elsevier
Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is
essential for designing more efficient nanoparticles for oral administration. The …

Translational considerations in nanomedicine: the oncology perspective

AA Gabizon, RTM de Rosales, NM La-Beck - Advanced Drug Delivery …, 2020 - Elsevier
Nanoparticles can provide effective control of the release rate and tissue distribution of their
drug payload, leading to major pharmacokinetic and pharmacodynamic changes vis-à-vis …

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake

CD Walkey, JB Olsen, H Guo, A Emili… - Journal of the …, 2012 - ACS Publications
Delivery and toxicity are critical issues facing nanomedicine research. Currently, there is
limited understanding and connection between the physicochemical properties of a …

[HTML][HTML] Introduction to nanomedicine

D Astruc - Molecules, 2015 - mdpi.com
Although mentions of nanoparticles in relation to biomedicine appeared in the late 1970s
and are now the subject of over 10,000 publications per year, the term “Nanomedicine” only …

Theranostic nanoparticles engineered for clinic and pharmaceutics

X Ma, Y Zhao, XJ Liang - Accounts of chemical research, 2011 - ACS Publications
Nanomedicine is the manipulation of human biological systems at the molecular level using
nanoscale or nanostructured materials. Because nanoscale materials interact effectively …

Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

M Pourmadadi, MM Eshaghi, S Ostovar… - Journal of Drug Delivery …, 2023 - Elsevier
The emergence of nanomedicine drugs as a result of the fast advancement of
nanotechnology offers enormous potential for improving cancer treatment strategies. The …

Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics

A Salvati, C Åberg, T dos Santos, J Varela… - … , Biology and Medicine, 2011 - Elsevier
Central to understanding how nanoscale objects interact with living matter is the need for
reproducible and verifiable data that can be interpreted with confidence. Likely this will be …

[HTML][HTML] Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines

T Dos Santos, J Varela, I Lynch, A Salvati, KA Dawson - PloS one, 2011 - journals.plos.org
Nanotechnology is expected to play a vital role in the rapidly developing field of
nanomedicine, creating innovative solutions and therapies for currently untreatable …