Senile plaques are neuropathological manifestations in Alzheimer's disease (AD) and are
composed mainly of extracellular deposits of amyloid β‐peptide (Aβ). Various data suggest …

Increased oxidative stress resulting from free radical damage to cellular function is
associated with a number of neurodegenerative diseases, in particular with Alzheimer's …

The aetiologies of Alzheimer's disease (AD) are complex and multifactorial. Current
therapies are largely ineffective, as the pathophysiological pathways are poorly understood …

Alzheimer's disease is widely held to be associated with oxidative stress due, in part, to the
action of amyloid bpeptide (Ab). We observed that Ab 25–35 induced an increase in reactive …

Glutathione (GSH) is an important endogenous antioxidant found in millimolar
concentrations in the brain. GSH levels have been shown to decrease with aging …

The reaction of proteins with reducing sugars leads to the formation of 'advanced glycation
endproducts'(AGEs). They accumulate in Alzheimer's disease brain in the vicinity of β …

Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's
disease (PD). In order to study viral vector-mediated overexpression of the antioxidant …

Polyunsaturated fatty acids (PUFA) in membrane lipids are prone to attack by reactive
oxygen species (ROS), and the resulting lipid peroxidation can cause injury and death of …

Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the
presence of extracellular senile plaques mainly composed of amyloid-β peptide (Aβ) …

Amyloid-β (A β) peptides are components of senile plaques initiating degeneration of brain
neurons in Alzheimer's disease. They increase reactive oxygen species generation that may …