In two different medical centers, a total of 24 normal individuals (mean age, 31 years)
participated in a double-masked, three-way crossover single-instillation comparison of …

• The effect of topical timolol maleate on exercise performance was investigated in a
randomized double-blind study. Healthy young subjects underwent two graded maximal …

Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have
been measured in a single dose double-blind crossover study in six healthy volunteers. Both …

We studied the effects on efficacy and safety of varying the drop size of a topical solution of
levobunolol 0.5%. In a double-masked, crossover acute study, we administered a single …

• Betaxolol, a new β 1-adrenergic blocker, was applied to 20 eyes of ten patients with ocular
hypertension. Topical 0.25% betaxolol was found to significantly lower intraocular pressure …

Purpose To compare the effects of 0.5% aqueous timolol and 0.5% timolol gellan on
exercise performance in middle-aged men. Methods We evaluated the effects of 0.5 …

Topical glaucoma therapies may induce adverse systemic side effects. This study was
designed to determine the potential for drug-induced cardiovascular side effects of various …

Background: There is evidence that the ocular hypotensive effect of topical betablockers
persists for at least 24 hours once beta-blockade has been achieved. In previous studies …

• Betaxolol hydrochloride, 0.5%, and timolol maleate, 0.5%, were compared in a 26-week
randomized, double-masked study involving 46 patients with primary open-angle glaucoma …

The effect on intraocular pressure (IOP) of topical timolol was studied in 30 patients with
arterial hypertension treated with oral alprenolol, metoprolol or timolol. No patient had any …