Objective By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4,
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …

Chronic low-grade inflammation is an important contributor to the development of insulin
resistance, a hallmark of type 2 diabetes mellitus (T2DM). Obesity and high-fat feeding lead …

Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …

Objective—Obesity is associated with insulin resistance and adipose tissue inflammation.
Reactive oxygen species (ROS) increase in adipose tissue during the development of …

Aims/hypothesis Upregulation of the reactive oxygen species (ROS)-producing enzyme
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

OBJECTIVE: NADPH oxidase 4 (NOX4) is a reactive oxygen species (ROS) producing
NADPH oxidase that regulates redox homeostasis in diverse insulin-sensitive cell types. In …

Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

Inflammasomes are multiprotein inflammatory platforms that induce caspase-1 activation
and subsequently interleukin (IL)-1β and IL-18 processing. The NLRP3 inflammasome is …

Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …