Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the
human motor system. Aetiological mechanisms implicated in the development of ALS have …

Synopsis Riluzole, a benzothiazole, affects neurons by 3 mechanisms: by inhibiting
excitatory amino acid release, inhibiting events following stimulation of excitatory amino acid …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

Riluzole, a benzothiazole derivative, has been shown to be effective in prolonging survival
in amyotrophic lateral sclerosis. The mechanisms by which riluzole exerts neuroprotective …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by
the death of motor neurons. Riluzole is a benzothiazole derivative that blocks glutamatergic …

Over the past decades, a multitude of experimental drugs have been shown to delay
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …

Riluzole is an established therapy for amyotrophic lateral sclerosis (ALS), although its effects
are modest, prolonging survival by three months on average. While the neuroprotective …

Tremendous advances in our understanding of pathogenesis of amyotrophic lateral
sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique …

Amyotrophic lateral sclerosis (ALS) is the commonest form of motor neuron disease and is a
fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the …

Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose
hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and …