Significance: Cardiovascular diseases (CVD) represent a major public health burden. High
low-density lipoprotein (LDL)-cholesterol is a recognized pathogenic factor for …

Atherosclerosis and its complications represent the major cause of death in developed
countries. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A [HMGCoA] …

Significance: Endothelial dysfunction and the imbalance between nitric oxide (NO) and
reactive oxygen species production in the vascular endothelium are important early steps in …

Endothelial dysfunction is recognized as an early event in the pathogenesis of
atherosclerosis. Many risk factors cause endothelial dysfunction, such as …

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are
successfully used for the treatment of hypercholesterolemia and profoundly reduce …

The beneficial effects of statins, the most widely prescribed class of drugs in the world, are
now recognized to extend well beyond their lipid-lowering properties. Through a …

Vascular oxidative stress is a key feature of atherogenesis, and targeting vascular redox
signalling is a rational therapeutic goal in vascular disease pathogenesis. 3-hydroxy-3 …

Statins have emerged as a highly efficacious class of drugs in the prevention of
cardiovascular events. The primary mechanism of its cardioprotective effect is likely through …

Endothelial dysfunction has been shown to be a prognostic factor for cardiovascular disease
and improvement of endothelial dysfunction prevents cardiovascular event presentation …

As the major regulator of vascular homeostasis, the endothelium exerts a number of
vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and …