Proteomics of human neurodegenerative diseases

J Zhang, CD Keene, C Pan, KS Montine… - … of Neuropathology & …, 2008 - academic.oup.com
The technology, experimental approaches, and bioinformatics that support proteomic
research are evolving rapidly. The application of these new capabilities to the study of …

Clinical proteomics in neurodegenerative diseases

JY Zhou, J Hanfelt, J Peng - PROTEOMICS–Clinical …, 2007 - Wiley Online Library
Investigation of the human specimens is an essential element for understanding the
pathogenesis of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's …

Biomarker discovery in neurodegenerative diseases: a proteomic approach

M Shi, WM Caudle, J Zhang - Neurobiology of disease, 2009 - Elsevier
Biomarkers for neurodegenerative disorders are essential to facilitate disease diagnosis,
ideally at early stages, monitor disease progression, and assess response to existing and …

Clinical proteomics in neurodegenerative disorders

H Zetterberg, U Rüetschi, E Portelius… - Acta Neurologica …, 2008 - Wiley Online Library
Neurodegenerative disorders are characterized by neuronal impairment that eventually
leads to neuronal death. In spite of the brain's known capacity for regeneration, lost neurons …

Proteomics of neurodegenerative diseases: analysis of human post‐mortem brain

KW Li, AB Ganz, AB Smit - Journal of neurochemistry, 2019 - Wiley Online Library
Dementias are prevalent brain disorders in the aged population. Dementias pose major
socio‐medical burden, but currently there is no cure available. Novel proteomics …

New insight into neurodegeneration: the role of proteomics

R Pal, G Alves, JP Larsen, SG Møller - Molecular neurobiology, 2014 - Springer
Recent advances within the field of proteomics, including both upstream and downstream
protocols, have fuelled a transition from simple protein identification to functional analysis. A …

Proteomics of human cerebrospinal fluid: discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics

AC Kroksveen, JA Opsahl, TT Aye, RJ Ulvik… - Journal of …, 2011 - Elsevier
There is an urgent need for novel biomarkers that can be used to improve the diagnosis,
predict the disease progression, improve our understanding of the pathology or serve as …

The potential of proteomics in understanding neurodegeneration

R Pal, JP Larsen, SG Moller - International review of neurobiology, 2015 - Elsevier
Neurodegenerative diseases are a major health concern worldwide. Diseases such as
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

The challenge to search for new nervous system disease biomarker candidates: the opportunity to use the proteogenomics approach

TGM Nery, EM Silva, R Tavares, F Passetti - Journal of Molecular …, 2019 - Springer
Alzheimer's disease, Parkinson's disease, prion diseases, schizophrenia, and multiple
sclerosis are the most common nervous system diseases, affecting millions of people …

Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases

J Zhang, DR Goodlett… - Journal of Alzheimer's …, 2005 - content.iospress.com
The clinical diagnosis of major neurodegenerative disorders, eg Alzheimer's disease,
Parkinson's disease, and dementia with Lewy body, remains unsatisfactory based on current …