Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

J. Neurochem.(2010) 113, 389–401. Abstract Alzheimer's disease (AD), a progressive
neurodegenerative disease characterized by the accumulation of amyloid‐β protein and …

Alzheimer's disease (AD) brains contain large numbers of amyloid-β peptide (Aβ) deposits
associated with activated microglia, astrocytes and dystrophic neurites. Activated …

Background The complement system is part of the innate immune system that clears
pathogens and cellular debris. In the healthy brain, complement influences …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

Abnormal accumulation of β-amyloid (Aβ) in Alzheimer's disease (AD) is associated with
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …