Patients selected for dual pathway inhibition in clinical practice have similar characteristics and outcomes to those included in the COMPASS randomized trial: The …

KAA Fox, V Aboyans, ES Debus… - European Heart …, 2022 - academic.oup.com
Aims To determine the characteristics of patients with coronary artery disease (CAD),
peripheral artery disease (PAD), or both, initiating dual pathway inhibition (DPI) using …

Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet …

M Galli, F Franchi, F Rollini, L Been… - European Heart …, 2022 - academic.oup.com
Aims Dual pathway inhibition (DPI) by adding a vascular dose of rivaroxaban to a single
antiplatelet agent has emerged as a promising antithrombotic strategy. However, in most …

Rivaroxaban plus aspirin versus aspirin alone in patients with prior percutaneous coronary intervention (COMPASS-PCI)

KR Bainey, RC Welsh, SJ Connolly, T Marsden… - Circulation, 2020 - Am Heart Assoc
Background: The COMPASS trial (Cardiovascular Outcomes for People using
Anticoagulation Strategies) demonstrated that dual pathway inhibition (DPI) with …

Synergy of dual pathway inhibition in chronic cardiovascular disease: lessons from the COMPASS trial

M Coppens, JI Weitz, JWA Eikelboom - Circulation research, 2019 - Am Heart Assoc
Although acetylsalicylic acid is of proven benefit for secondary prevention in patients with
cardiovascular disease, the risk of recurrent ischemic events remains high. Intensification of …

Dual pathway inhibition for atherosclerotic cardiovascular disease: Recent advances

S Carlin, TAC de Vries, A Budaj… - … Polska (Polish Heart …, 2022 - journals.viamedica.pl
Atherosclerotic cardiovascular disease (ASCVD), which includes coronary artery disease
(CAD), cerebrovascular disease, and peripheral arterial disease (PAD) is associated with …

Rivaroxaban plus aspirin for the prevention of ischaemic events in patients with cardiovascular disease: a cost-effectiveness study

S Petersohn, X Pouwels, B Ramaekers… - European journal of …, 2020 - academic.oup.com
Background Dual pathway inhibition with 2.5 mg rivaroxaban twice daily plus 100 mg aspirin
once daily may be a promising alternative to 100 mg aspirin antiplatelet therapy for the …

Efficacy and safety of dual-pathway inhibition in patients with cardiovascular disease: a meta-analysis of 49 802 patients from 7 randomized trials

M Galli, D Capodanno, S Benenati… - European Heart …, 2022 - academic.oup.com
Aims Low-dose (LD) direct oral anticoagulants (DOACs) in adjunct to antiplatelet therapy,
known as dual-pathway inhibition (DPI), have been tested to prevent ischaemic events in …

Pharmacodynamic profiles of dual-pathway inhibition with or without clopidogrel versus dual antiplatelet therapy in patients with atherosclerotic disease

M Galli, F Franchi, F Rollini, L Been… - Thrombosis and …, 2022 - thieme-connect.com
Aim Inhibition of thrombin-mediated signaling processes using a vascular dose of
rivaroxaban in adjunct to antiplatelet therapy, known as dual-pathway inhibition (DPI) …

Switching from dual antiplatelet therapy with aspirin plus a P2Y12 inhibitor to dual pathway inhibition with aspirin plus vascular-dose rivaroxaban: the Switching Anti …

L Ortega-Paz, F Franchi, F Rollini… - Thrombosis and …, 2024 - thieme-connect.com
Background To date, there are no data on switching to dual pathway inhibition (DPI) patients
who have completed a guideline-recommended dual antiplatelet therapy (DAPT) regimen …

Dual pathway inhibition in patients with atherosclerotic disease: pharmacodynamic considerations and clinical implications

M Galli, F Franchi, F Rollini, L Ortega-Paz… - Expert review of …, 2023 - Taylor & Francis
Introduction The persistence of elevated rates of ischemic recurrences despite the use of
antiplatelet therapy among patients with atherosclerotic disease together with the …