Clear Victory for Chlamydia: The Subversion of Host Innate Immunity

H Chen, Y Wen, Z Li - Frontiers in microbiology, 2019 - frontiersin.org
As obligate intracellular bacterial pathogens, members of the Chlamydia genera are the
pivotal triggers for a wide range of infections, which can lead to blinding trachoma, pelvic …

Transcription factor complex AP‐1 mediates inflammation initiated by Chlamydia pneumoniae infection

A Wang, M Al‐Kuhlani, SC Johnston… - Cellular …, 2013 - Wiley Online Library
C hlamydia pneumoniae is responsible for a high prevalence of respiratory infections
worldwide and has been implicated in atherosclerosis. Inflammation is regulated by …

Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk …

Z Lin, X Li, H Shi, R Cao, L Zhu, C Dang… - Frontiers in …, 2024 - frontiersin.org
Background Cervical carcinoma (CC) represents a prevalent gynecological neoplasm, with
a discernible rise in prevalence among younger cohorts observed in recent years …

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

ATY Yeung, C Hale, AH Lee, EE Gill, W Bushell… - Nature …, 2017 - nature.com
Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections
and preventable blindness worldwide. There are, however, limited in vitro models to study …

Reorganization of the host cytoskeleton by the intracellular pathogen Chlamydia trachomatis

Y Kumar, RH Valdivia - Communicative & integrative biology, 2008 - Taylor & Francis
Chlamydiae are obligate intracellular pathogens that cause a wide range of human
diseases. Chlamydia resides in a membrane bound vacuole (“inclusion”) that expands to …

Quantitative protein profiling of Chlamydia trachomatis growth forms reveals defense strategies against tryptophan starvation

O Østergaard, F Follmann, AW Olsen… - Molecular & Cellular …, 2016 - ASBMB
Chlamydia trachomatis is one of the most common sexually transmitted bacterial pathogens
in humans. The infection is often asymptomatic and can lead to chronic manifestations. The …

Diverse requirements for SRC-family tyrosine kinases distinguish chlamydial species

J Mital, T Hackstadt - MBio, 2011 - Am Soc Microbiol
Chlamydiae are well known for their species specificity and tissue tropism, and yet the
individual species and strains show remarkable genomic synteny and share an intracellular …

Chlamydial intracellular survival strategies

RJ Bastidas, CA Elwell… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the
causative agent of blinding trachoma. Although Chlamydia is protected from humoral …

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the …

YS Chen, RJ Bastidas, HA Saka, VK Carpenter… - PLoS …, 2014 - journals.plos.org
Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted infections,
employs a type III secretion (T3S) system to deliver effector proteins into host epithelial cells …

Single‐cell landscape highlights heterogenous microenvironment, novel immune reaction patterns, potential biomarkers and unique therapeutic strategies of cervical …

J Qiu, X Qu, Y Wang, C Guo, B Lv, Q Jiang… - Advanced …, 2023 - Wiley Online Library
Cervical adenocarcinomas (ADCs), including human papillomavirus (HPV)‐associated
(HPVA) and non‐HPVA (NHPVA), though exhibiting a more malignant phenotype and …