A combined modeling approach was used to identify structural factors that underlie the
structure–activity relationships (SARs) of full dopamine D2 receptor agonists and structurally …

The aim of this study was to use a combined structure and pharmacophore modeling
approach to extract information regarding dopamine D1 receptor agonism and D1/D2 …

Homology model structures of the dopamine D2 receptor (D2R) were generated starting
from the active and inactive states of\upbeta β 2-adrenergic crystal structure templates. To …

The dopamine D1 receptor is a G protein-coupled receptor that regulates intracellular
signaling via agonist activation. Although the number of solved GPCR X-ray structures has …

The dopamine subtype 3 receptor (D3) is a promising therapeutic target for the treatment of
cocaine addiction, schizophrenia, Parkinson's disease, and other disorders, but little is …

This study is focused on the identification of structural features that determine the selectivity
of dopamine receptor agonists toward D1 and D2 receptors. Selective pharmacophore …

Targeting the D3 dopamine receptor (D3R) is a promising pharmacotherapeutic strategy for
the treatment of many disorders. The structure of the D3R is similar to the D2 dopamine …

A pharmacophore model for dopamine D 4 antagonists has been developed on the basis of
a previously reported dopamine D 2 model. By using exhaustive conformational analyses …

The molecular alignments obtained from a previously reported pharmacophore model have
been employed in a three-dimensional quantitative structure− activity relationship (3D …

Dopamine (DA) receptors, a class of G-protein coupled receptors (GPCRs), have been
targeted for drug development for the treatment of neurological, psychiatric and ocular …