Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin
research has focused on SirT1, which deacetylates transcription factors and cofactors in the …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized
to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major
aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive …

Mitochondria play a central role in the production of reactive oxygen species as byproducts
of metabolism and energy production. In order to protect cellular structures from oxidative …

Aims: Sirtuins, a family of NAD+-dependent deacetylases, are recognized as
nondispensable regulators of aging processes. Sirtuin 3 (SIRT3) is the main mitochondrial …

Mitochondria play a critical role in energy production, cell signalling and cell survival.
Defects in mitochondrial function contribute to the ageing process and ageing-related …

Despite recent controversy about their function in some organisms, sirtuins are thought to
play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging …

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous
mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is …